Nanoparticulate Materials and Methods for Targeting Iron Acquisition and Metabolism for Treating Bacterial Infections

摘要

Novel biocompatible nanoparticles preferably based on a calcium or gallium analogue of Prussian blue, or independently an analogue of magnesium, or aluminum were designed and synthesized to take advantage of their ability to penetrate the bacterial cell membrane of the invading pathogen in an animal such as a human in both Gram-positive bacteria (e.g. Staphylococcus aureus) and Gram-negative bacteria (e.g. Pseudomonas aeruginosa), and undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications.