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STRAIN OF BACTERIA PRODUCING DHA AND EPA, SIX GENE FRAGMENTS IN THE BACTERIAL GENOME AND THEIR APPLICATIONS
STRAIN OF BACTERIA PRODUCING DHA AND EPA, SIX GENE FRAGMENTS IN THE BACTERIAL GENOME AND THEIR APPLICATIONS
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机译:细菌基因组中生产DHA和EPA的细菌菌株,六基因片段及其应用
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摘要
The present invention discloses a strain of bacteria producing DHA and/or EPA, six gene fragments in the bacterial genome, and uses thereof. The strain is Schizoochytrium limacinum HS01, which has the accession number of CGMCC No. 13746 at China General Microbiological Culture Collection Center. The six gene fragments are composed of gene fragment 1 to gene fragment 6, and the nucleotide sequences are sequentially as shown in SEQ ID NO: 3 to SEQ ID NO: 8 in the Sequence Listing. The experiments prove that fermentation broth containing DHA and EPA can be obtained by fermenting Schizoochytrium limacinum HS01; the recombinant strain is obtained by introducing gene fragment 1 to gene fragment 6 into Schizoochytrium limacinum MYA-1381; the ability the recombinant strain for producing DHA and EPA is greatly improved. The bacteria provided by the invention, the six gene fragments, the protein encoded by these six gene fragments, the vector, the cell or the organism containing these six gene fragments all have important application values.
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机译:本发明公开了产生DHA和/或EPA的细菌菌株,细菌基因组中的六个基因片段及其用途。该菌株是 Schizoochytrium limacinum I> HS01,在中国通用微生物培养物保藏中心的登录号为CGMCC No. 13746。六个基因片段由基因片段1至基因片段6组成,并且核苷酸序列顺序如序列表中的SEQ ID NO:3至SEQ ID NO:8所示。实验证明,通过发酵 Schizoochytrium limacinum I> HS01可以得到含DHA和EPA的发酵液。将基因片段1和基因片段6导入 Schizoochytrium limacinum I> MYA-1381中,得到重组菌株。重组菌株产生DHA和EPA的能力大大提高。本发明提供的细菌,六个基因片段,由这六个基因片段编码的蛋白质,包含这六个基因片段的载体,细胞或生物均具有重要的应用价值。
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