首页>
外国专利>
Method for Constructing PD-1 Gene Modified Humanized Animal Model and Use Thereof
Method for Constructing PD-1 Gene Modified Humanized Animal Model and Use Thereof
展开▼
机译:PD-1基因修饰的人源化动物模型的构建方法及其应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.
展开▼