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SCREENING OF T LYMPHOCYTES FOR CANCER-SPECIFIC ANTIGENS
SCREENING OF T LYMPHOCYTES FOR CANCER-SPECIFIC ANTIGENS
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机译:筛选针对癌症抗原的T淋巴细胞
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摘要
Provided herein are methods to identify TCR-recognizing cancer-specific antigens, and TCR-engineered T cells having antigen-specific cytotoxic activity. Provided herein are engineered T lymphocytes produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the engineered T lymphocytes described herein. Provided herein are antibodies, or fragments thereof, produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the antibodies described herein to a subject. In some embodiments, the therapeutic compositions (e.g., engineered lymphocytes, antibodies, etc.) and methods herein are provided as part of a kit or system.
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