METHOD FOR DIAGNOSING CHRONIC OBSTRUCTIVE AIRWAY DISEASE THROUGH BACTERIAL METAGENOME ANALYSIS

摘要

The present invention relates to a method of diagnosing chronic obstructive airway disease such as asthma, COPD, and the like through bacterial metagenomic analysis, and more particularly, to a method of diagnosing chronic obstructive pulmonary disease and asthma by analyzing an increase or decrease in content of extracellular vesicles derived from specific bacteria through bacterial metagenomic analysis using a subject-derived sample. Extracellular vesicles secreted from bacteria present in the environment are absorbed into the human body, and thus may directly affect inflammatory responses, and it is difficult to diagnose chronic obstructive airway diseases such as asthma, COPD, and the like early before symptoms occur, and thus efficient treatment therefor is difficult. Thus, according to the present invention, a risk of developing chronic obstructive airway diseases such as asthma, COPD, and the like can be predicted through metagenomic analysis of a gene present in bacteria-derived extracellular vesicles by using a human body-derived sample, and thus the onset of chronic obstructive airway diseases can be delayed or prevented through appropriate management by early diagnosis and prediction of a risk group for chronic obstructive airway diseases, and, even after chronic obstructive airway diseases such as asthma, COPD, and the like occur, early diagnosis therefor can be implemented, thereby lowering the incidence rate of chronic obstructive airway diseases and increasing therapeutic effects.