TARGETED T CELLS WITH CYTOTOXICITY TOWARD IMMUNOSUPPRESSIVE CELLS

摘要

Described herein are methods for producing and utilizing T cells comprising a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain specific for a target tumor antigen, and a polypeptide comprising an extracellular antigen binding domain specific for an extracellular polypeptide expressed on an immunosuppressive cell. The technology described herein is related to methods of treating cancer, specifically solid tumors, by targeting immunosuppressive cells found within the tumor microenvironment.