ORAL ANTICANCER PRODRUGS, THEIR PREPARATION METHODS AND APPLICATIONS

摘要

Described herein are anticancer complexes suitable for oral administration comprising an anticancer prodrug moiety comprising (i) a caspase-cleavable peptide, attached directly or through a linker, to (ii) an anticancer chemotherapeutic agent; and (b) a bile acid moiety, wherein the bile acid moiety is non-covalently complexed to the anticancer prodrug moiety. Also described is the preparation of such anticancer complexes and their use in combination with a treatment that induces apoptosis (e.g., radiotherapy) for inducing amplified apoptosis of tumor cells and treating cancer.