COORDINATED IN VITRO AND IN SILICO BASED APPROACH FOR PREDICTING NANOMATERIAL BIODISTRIBUTION

摘要

Disclosed herein is a new system that eliminates the need for animal testing of nanomaterial (NM) biodistribution. The system involves a streamlined in vitro assay that is merged with in-silico approaches that enable accurate prediction of the biodistribution of a variety of NMs in the body. Due to the design of certain embodiments, unprecedented resolution is obtained, where cellular level knowledge/cellular resolution in tissues in the body is delivered for the first time.