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TETRAVALENT ANTI-PSGL-1 ANTIBODIES AND USES THEREOF
TETRAVALENT ANTI-PSGL-1 ANTIBODIES AND USES THEREOF
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机译:四价抗PSGL-1抗体及其用途
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摘要
Provided herein are tetravalent antibodies that specifically bind to human PSGL-1. Unlike bivalent antibodies, these tetravalent antibodies contain a dimer of two monomers, with each monomer comprising two light chain variable (VL) domains and two heavy chain variable (VH) domains. This format allows for cross-linker/FcR-expressing cell-independent tetravalent antibodies against PSGL-1 that show enhanced efficacy as compared to bivalent PSGL-1 antibodies. These tetravalent antibodies can be used in a variety of diagnostic and therapeutic methods, including without limitation treating T-cell mediated inflammatory diseases, transplantations, and transfusions.
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