CELL MEMBRANE COATED MAGNETIC NANOPARTICLES AND ASSAYS FOR IDENTIFICATION OF TRANSMEMBRANE PROTEIN-BINDING COMPOUNDS

摘要

Disclosed herein are nanostructures comprising a cell membrane-derived material comprising a target membrane protein; and one or more magnetic nanoparticles; wherein the cell membrane-derived material encapsulates the one or more magnetic nanoparticles. Also disclosed are methods of screening a sample for a binding agent, the method comprising contacting a sample comprising a binding agent with a nanostructure to form a mixture, the nanostructure comprising a cell membrane-derived material comprising a target membrane protein; and one or more magnetic nanoparticles; wherein the cell membrane-derived material encapsulates the one or more magnetic nanoparticles; and separating the nanostructure and any binding agent bound thereto from the mixture with a magnet.