WOUND DRESSING FOR THE HARVESTING OF SUPERFICIAL EPIDERMAL GRAFTS

摘要

In some aspects, the present invention provides an active dressing for transfer of superficial epidermal biopsies to a wound site, where the dressing can enhance keratinocyte out growth from the biopsies at the wound site and improve the rate of re-epithelization. In some embodiments, the dressing can include a perforated dehydrated amniotic membrane sheet that is coupled to a backing sheet having suitable adhesive properties. The perforations can have appropriate dimensions and distributions for capturing and transferring the skin biopsies. Without being limited to any particular theory, the amniotic membrane sheet can enhance the re-epithelization of the wound site to which the biopsies are transferred, e.g., by supplying signaling proteins and extra-cellular matrix (ECM) components.