AAPTAMINE ALKALOID DERIVATIVES AND SYNTHESIS METHOD AND APPLICATION THEREOF

摘要

A benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof, the structure of the compound being shown in general formula (I).; ;in the formula (I), R₁, R₂ and R₃ independently are hydrogen, C_1-4 alkyl or C_1-4 alkanoyl; one from among R₄ and R₅ is a benzene ring or a substituted benzene ring, while the other is hydrogen, a benzene ring or a substituted benzene ring, wherein a substituent group on the substituted benzene ring is hydroxyl, cyano, amino, halogen, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 alkylamine, C_1-4 alkanoyl or C_1-4 alkoxyacyl. A method for synthesizing the compound and a use in the preparation of anti-tumor drugs. The compound shown in formula (I) may be used for preparing anti-tumor, especially anti-lung cancer, drugs as well as anti-fungal drugs.