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Stabilized Aqueous Compositions of Neuromuscular Blocking Agents
Stabilized Aqueous Compositions of Neuromuscular Blocking Agents
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机译:神经肌肉阻滞剂的稳定水组合物
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摘要
The present invention relates to an aqueous composition comprising:(i) a steroidal neuromuscular blocking agent that is a Rocuronium salt, further wherein the steroidal neuromuscular blocking agent is present at a concentration ranging from 5 mg/mL to 20 mg/mL based on the total volume of the aqueous composition; and(ii) an excipient that includes D-gluconic acid, D-glucono-delta-lactone, or a combination thereof, where the steroidal neuromuscular blocking agent and the excipient are dissolved in a solution consisting of water.;Furthermore the present invention relates to a liquid pharmaceutical composition comprising or consisting of said aqueous composition and a method for producing said aqueous composition.
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