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NOVEL MICRORNA INHIBITOR THERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS
NOVEL MICRORNA INHIBITOR THERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUS
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机译:系统性红斑狼疮的新型微RNA抑制剂治疗
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摘要
Disclosed are novel compositions and methods for treating systemic lupus erythematosus (SLE) as well as a model for measuring the efficacy of said treatments. Specifically, the disclosure provides a non-human animal model for SLE comprising a severe combined immunodeficient non-human animal comprising exogenous cells from a human subject with SLE, wherein the cells from the human subject are peripheral blood mononuclear cells. Further disclosed is a method of screening for a drug candidate that inhibits or reduces SLE using a severe combined immunodeficient non-human animal.
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