The invention relates to a transdermal peptide with a nuclear localization ability and having an amino acid sequence as shown in SEQ ID NO: 1. The invention provides a fusion protein with a nuclear localization ability, which comprises a macromolecular protein with one end being linked to the transdermal peptide. The invention also discloses the use of the transdermal peptide in the preparation of a medicament or a transdermal preparation for treating skin diseases. The invention further provides a medicament for treating a skin disease, comprising the transdermal peptide and a pharmaceutically acceptable excipient. The transdermal peptide enters the cells autonomously to locate in the nuclei, and can penetrate through the stratum corneum of the skin into cells in the dermis. The peptide is conveniently synthesized artificially and suitable for transdermal administration, and has a therapeutic potential via transdermal administration by carrying a drug for treating skin diseases.
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机译:本发明涉及一种具有核定位能力并具有如SEQ ID NO:1所示的氨基酸序列的透皮肽。本发明提供了一种具有核定位能力的融合蛋白,其包括一端连接至其的大分子蛋白。透皮肽。本发明还公开了透皮肽在制备用于治疗皮肤疾病的药物或透皮制剂中的用途。本发明进一步提供了用于治疗皮肤疾病的药物,其包含透皮肽和药学上可接受的赋形剂。透皮肽自动进入细胞以定位在细胞核中,并且可以穿透皮肤的角质层进入真皮中的细胞。该肽方便地人工合成并适合于经皮给药,并且通过携带用于治疗皮肤疾病的药物而经皮给药具有治疗潜力。
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