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MAMMALIAN CELLS FOR PRODUCING ADENO-ASSOCIATED VIRUSES
MAMMALIAN CELLS FOR PRODUCING ADENO-ASSOCIATED VIRUSES
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机译:产生腺相关病毒的哺乳动物细胞
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摘要
A mammalian cell comprising at least four distinct recombination target sites (RTS), an adenovirus (Ad) gene comprising E1A, E1B or a combination thereof, and a promoter operatively linked to the Ad gene, wherein the RTS, the Ad gene, and the promoter are chromosomally-integrated; methods for using the cell for generating a recombinant adeno-associated virus (rAAV) producer host cell; and methods for using the AAV producer host cell to produce, package and purify rAAV.
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