METHODS FOR PROTEIN TYROSINE PHOSPHORYLATION PROFILING WITH VARIANT SH2 DOMAINS

摘要

There is provided method of profiling protein tyrosine phosphorylation of a sample, the method comprising: contacting the sample with an SH2 Superbinder in order to bind pTyr-including peptides contained in the sample with the SH2 Superbinder; isolating the bound pTyr-including peptides from the sample; and identifying the isolated pTyr-including peptides.