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Platform and Method for Identifying Past Exposure to Chemical Agents or Heavy Metals

机译:识别化学试剂或重金属过去接触的平台和方法

摘要

A method for determining past exposure to chemical agents or heavy metals may include coating a capture material with a capture reagent. The capture reagent may be selected based on an ability of the capture reagent to bind with a target antibody, and the target antibody may be an indicator associated with a particular chemical agent or heavy metal. The method may further include interrogating a clinical sample associated with an individual by forming a mixture of the capture material and the clinical sample, and determining an exposure status of the individual to the particular chemical agent or heavy metal based on whether the capture material demonstrates capture of the indicator.
机译:用于确定过去对化学试剂或重金属的暴露的方法可以包括用捕获试剂涂覆捕获材料。可以基于捕获试剂与靶标抗体结合的能力来选择捕获试剂,并且靶标抗体可以是与特定化学试剂或重金属相关的指示剂。该方法可以进一步包括通过形成捕获材料和临床样品的混合物来询问与个体相关的临床样品,并且基于捕获材料是否显示出捕获来确定个体对特定化学试剂或重金属的暴露状态。指标。

著录项

  • 公开/公告号US2020102552A1

    专利类型

  • 公开/公告日2020-04-02

    原文格式PDF

  • 申请/专利权人 JOHN HOPKINS UNIVERSITY;

    申请/专利号US201916532020

  • 发明设计人 MEKBIB ASTATKE;

    申请日2019-08-05

  • 分类号C12N15/10;C12Q1/6883;G01N33/68;C12Q1/6804;

  • 国家 US

  • 入库时间 2022-08-21 11:20:34

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