USE OF Y PEPTIDE IN PREPARATION OF DRUG OR HEALTHCARE PRODUCT FOR LOWERING BLOOD PRESSURE

摘要

Disclosed is use of a YY-dipeptide in the manufacture a medicament or a healthcare product for lowering blood pressure. In the present disclosure, ACE inhibitory activities of dipeptides are virtually screened by means of a molecular docking method and a self-developed software, based on the determined crystal structure of ACE enzyme. The dipeptides obtained by the virtual screening were experimentally verified for the ACE inhibitory activity thereof. As a result, the YY-dipeptide is found to have relatively good ACE inhibitory activity. A peptide or protein composed of multiple tyrosine residues can be hydrolyzed into an active YY-peptide in vivo, and produce the same or a similar effect.