首页>
外国专利>
EXPRESSION OF VALLEY FEVER SEQUENCES IN PLANTS AND PLANT PRODUCED VACCINES FOR SAME
EXPRESSION OF VALLEY FEVER SEQUENCES IN PLANTS AND PLANT PRODUCED VACCINES FOR SAME
展开▼
机译:谷粒热序列在植物和植物产生的相同疫苗中的表达
展开▼
页面导航
摘要
著录项
相似文献
摘要
Vaccines, methods of producing, and methods of using are provided in which a protective response to Valley Fever disease is produced when administered to an animal. The vaccine provides for expression of Coccidioides sp. Ag2 polypeptide in a plant or plant part, linked to a promoter preferentially directing expression to seed tissue of the plant or plant part. Further embodiments provide the polypeptide is targeted to the cell wall, vacuole or endoplasmic reticulum. The polypeptide may be fused to a dendritic cell targeting dendritic cell or a heat labile enterotoxin. Increased expression levels in the plant or plant part are obtained. The vaccine comprising the plant-produced Ag2 polypeptide may be a glucan chitin particle comprising the Ag2 polypeptide. The plant or plant materials in an embodiment may be orally administered.
展开▼