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SPLIT INTEIN MEDIATED POLYMERIZATION AND PRODUCTION OF MUSSEL FOOT ADHESIVE PROTEIN MATERIALS
SPLIT INTEIN MEDIATED POLYMERIZATION AND PRODUCTION OF MUSSEL FOOT ADHESIVE PROTEIN MATERIALS
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机译:分裂蛋白介导的聚合反应和Mussel脚胶材料的生产
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摘要
Mussels strongly adhere to a variety of surfaces by secreting byssal threads that contain mussel foot proteins (Mfps). Recombinant production of Mfps presents an attractive route for preparing advanced adhesive materials. Using synthetic biology strategies, Mfp5 together with Mfp5 oligomers containing two or three consecutive, covalently-linked Mfp5 sequences (named Mfp52 and Mfp53) were synthesized. Positive correlations were found between Mfp5 molecular weight and underwater adhesive properties, including adhesion force, adhesion work, protein layer thickness, and recovery distance. Dopa-modified Mfp53 displayed a high adhesion force (201±36 nN μm1) and a high adhesion work (68±21 fJ μm−1) for 200 s cure times, higher than previously reported Mfp-mimetic adhesives. Results disclosed herein highlight the power of synthetic biology in producing biocompatible and highly adhesive Mfp-based materials.
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