ANTIBODY, ANTIGEN BINDING FRAGMENT, KITS OR COMPOSITIONS, MUTATED NT-PROBNP, POLYNUCLEOTIDE, HOST CELL, COMPOSITION, USE AND DIAGNOSIS OF HEART FAILURE IN A SUBJECT

摘要

the present invention relates to an antibody that specifically binds to a mutated nt-probnp comprising i) a mutation replacing arginine at position 46 with histidine or ii) a mutation replacing glutamic acid at position 43 with aspartic acid. moreover, the present invention relates to a mutated nt-probnp or fragment thereof. the present invention further contemplates kits comprising the antibody of the present invention or the mutated nt-probnp of the present invention. the present invention also relates to a method for diagnosing heart failure.