METHODS FOR INSULATING THE 3- (E) -ISOMER OF AN UNSATURED CARBOXYLIC ACID COMPOUND, TO PREPARE AN INSATURED 3- (E) -CARBOXYLIC ACID AND TO PREPARE (-) - AMBROX, E, 3- (E) / 7- (E) -HOMOPHARNESOIC ACID ALKYL ESTER.

摘要

the invention provides an improved method for isolating the 3- (e) -isomer of an unsaturated carboxylic acid from a mixture of corresponding (e / z) isomers. more particularly, the present invention relates to an improved method for the biocatalytic preparation of (3e, 7e) -homopharnesyl acid, as well as an innovative biocatalytic method for the improved preparation of homopharnesol, in particular (3e, 7e) -homopharnesol and homopharnesol preparations with a higher content of (3e, 7e) -homopharnesol. the present invention also relates to methods of preparing (-) - ambrox by applying (3e, 7e) -homopharnesyl acid or (3e, 7e) -homopharnesol as obtained according to the invention as a starting material.