ENZYMATIC PROCESSES FOR THE PREPARATION OF (±) -2- (DIFLUOROMETHYLIC) -1- (ALCOXICARBONYL) -CYCLOPROPANOCARBOXYLIC AND (±) -ACID 2- (VINYL) -1- (ALCOXICARBONYL) -CYCLOPROCANCHARCHONIC

摘要

methods for synthesizing 2- (difluoromethyl) -1- (alkoxycarbonyl) -cyclopropanecarboxylic acids and 2- (vinyl) -1- (alkoxycarbonyl) -cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt, are disclosed. methods for preparing (1r, 2r) -1 - ((tert-butoxycarbonyl) amino) -2- (difluoromethyl) cyclopropane-1-carboxylic acid and enantioenriched esters are also disclosed. these compounds are useful intermediates in the synthesis of viral protease inhibitors.