polynucleotides, isolated adenovirus, virus-like particle, vector, composition, cell and in vitro method for the production of an adenovirus or adenovirus-like particle

摘要

the present invention relates to new strains of adenovirus with high immunogenicity and without pre-existing immunity in the human population in general. the lack of pre-existing immunity is due to new hypervariable regions in the hexon protein of the adenoviral capsid. the new adenovirus strains also have an improved reproductive capacity. the present invention provides nucleotide sequences and amino acid sequences of these new adenovirus strains, as well as recombinant viruses, virus-like particles (vlps) and vectors based on those strains. in addition, pharmaceutical compositions and medical uses are provided in therapy or prophylaxis of a disease and methods for producing an adenovirus or virus-like particles using the new sequences, recombinant viruses, virus-like particles and vectors.