peptonucleic acid derivative, pharmaceutical composition, method for treating diseases or conditions involving the expression of the human tyrosinase gene, method for treating hyperpigmentation and use of the peptonucleic acid derivative

摘要

peptonucleic acid derivative, pharmaceutical composition, method for treating diseases or conditions involving the expression of the human tyrosinase gene, method for treating hyperpigmentation and use of the peptonucleic acid derivative. are peptonucleic acid derivatives that target a splice 3? of human tyrosinase pre-mRNA. derivatives of peptonucleic acid potently induce a splice variant of human tyrosinase mrna in cells and are useful for safely treating dermatological indications or conditions involving human tyrosinase protein after topical administration.