method of preparing cholic acid, method of preparing deoxycholic acid, method of preparing a compound of formula i-10, compound, pharmaceutical or cosmetic composition, method of preparing a compound of formula iii-8a, method of preparing acid chenodeoxycholic, high purity cholic acid composition, method for non-surgical removal of a fat deposit

摘要

the present disclosure provides methods of preparing cholic acid, deoxycholic acid or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and useful and innovative synthetic intermediates, for example, as described for methods 1, 1a , 1b, 2, 3, 3a and 4. the method can start with a plant-derived steroid as a starting material, such as dehydroepiandrosterone (dhea) or acetyl-dehydroepiandrosterone (ac-dhea). pharmaceutical or cosmetic compositions and uses thereof are also provided, comprising one or more of cholic acid, deoxycholic acid or kenodeoxycholic acid, an ester thereof, or a pharmaceutical or cosmetically acceptable salt thereof, which is of high purity, for example , free of impurities derived from animals.