MULTIPARTICULATED PHARMACEUTICAL FORM SUITABLE FOR UNIFORM RELEASE OF AN ACTIVE PHARMACEUTICAL INGREDIENT IN THE SMALL INTESTINE AND THE BIG INTESTINE, ITS PRODUCTION PROCESS AND ITS USE

摘要

"multiparticulate drug form comprising at least two differently coated pellet forms". the invention relates to a multiparticulate drug form for uniform release of an active pharmaceutical ingredient in the small intestine and large intestine, comprising at least two forms of pellets a and b comprising an active pharmaceutical ingredient in the core and having different polymer coatings that determine the release of the active ingredient at different pH values, characterized by the fact that the pellet form a is supplied with an internal polymer coating, and has an external enteric coating that quickly dissolves above the pH around 5.5, and the pellet form b is supplied with a polymer coating which, in the usp release test, releases less than 20% of the active ingredient at 6.8 ph in 6 hours and releases more than 50% of the active ingredient in ph of 7.2 in 6 hours. the invention further relates to a process for producing the multiparticulate drug form and the use of pellet forms a and b to produce the drug form.