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6、 Compounds and reduction methods of Dow (Divisional request 201900703)

机译:6,陶氏的化合物和还原方法(分项申请201900703)

摘要

The compounds provided are: M amp; eacute; all compounds related to efficacy and amp; eacute; tools for reducing the amount or activity of tau in C amp, eacute, Lula or animals, and in some cases for reducing the amount or activity of protein and AMP, Iacute, Na tau in C amp, eacute, Lula or animals. These compounds, M amp; eacute; all and synthesized potency and amp; eacute; uticas son amp; uacute; ntoma for improving at least one s amp; S amp; neurodegenerative diseases. These S amp; Iacute; ntomas, including P amp; eacute; memoranda.P amp; eacute; didda de la funci amp; oacute; n motora; and increased the number and / or number of nerve fibers. These neurodegenerative diseases include taupat amp, Iacute, as, Alzheimer's disease and prostate dementia.FTDP-17, par amp; Aacute; LISIS supraclear progressive (PSP),CEEROALPAT AMP;IACUTE;A TRAUM AMP;AACUTE;TICA CR AMP;OACUTE;NICA(CTE),Degeneraci Amp;Oacute;N Gangli Amp;Oacute;Nica Corticobasal(CBD),Epilepsia and S amp; Iacute; drome de Dravet. P
机译:提供的化合物有:M amp;敏锐与功效和放大器有关的所有化合物;敏锐用于减少Camp,eampute,Lula或动物中tau数量或活性的工具,以及在某些情况下减少Camp,eute,Lula或动物中tau蛋白和AMP的量或活性的工具。这些化合物,Mamp;敏锐全部和合成的效能和放大器;敏锐uticas儿子放大器; ac ntoma,用于提高至少一安培的电流;放大器;神经退行性疾病。这些样本不雅ntoma,包括P amp;敏锐备忘录敏锐Didda de la funci amp; ac摩托并增加了神经纤维的数量和/或数量。这些神经退行性疾病包括taupat amp,Iacute,如阿尔茨海默氏病和前列腺痴呆。急性LISIS核上超前(PSP),脑铝AMP; IACUTE; A TRAUM AMP; AACUTE; TICA CR AMP; OACUTE; NICA(CTE),Degeneraci Amp; Oacute; N Gangli Amp; Oacute; Nica Corticobasal(CBD),癫痫和S amp ;不雅德龙德德拉韦特。 P GT;

著录项

  • 公开/公告号CL2020000183A1

    专利类型

  • 公开/公告日2020-07-24

    原文格式PDF

  • 申请/专利权人 IONIS PHARMACEUTICALS INC.;

    申请/专利号CL20200000183

  • 发明设计人 KORDASIEWICZ HOLLY;

    申请日2020-01-21

  • 分类号C12N15/113;

  • 国家 CL

  • 入库时间 2022-08-21 11:18:03

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