A new ketamine prophet for Parkinson's disease

摘要

Abstract: the invention provides a compound of formula (I),They are catalphamine prophets for the treatment of diseases and neurodegenerative disorders The present invention also provides drug synthesis, including compounds of the invention, and methods for treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease. Therefore, the invention refers to formula compound (ID), wherein R1 is h, R2 is selected from one of the alternatives (I) and (II) listed below; or R1 is selected from one of the alternatives (I) and (II) listed below, R2 is h;O R1 and R2 are represented by the following substitutes (I); R1 and R2 are represented by the following substitutes (II); or R1 is substitutes (I) and R2 are substitutes (II);O R1 is the substitute (II), R2 is the substitute (I);(i) (I I) indicates the polymerization point, * the carbon atom of the polymerization point in substitute (I) is s configuration, or acceptable salt on the drug.