PTPRS and proteoglycans in autoimmune disease

摘要

Provided herein, inter alia, are PTPRS de-clustering agents and compositions and kits comprising the agents. Provided are methods of modulating extracellular matrix or decreasing fibroblast activity in a subject. Also provided are methods of treating subjects with or at risk of developing extracellular matrix diseases, fibroblast-mediated diseases, or autoimmune diseases.