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COMPOSITIONS AND PROCEDURES FOR TARGETING IN VITRO AND IN VIVO MEDICINE DELIVERY TO MAMMAL CELLS THROUGH BACTERIALLY DERIVATED INTAKE MINICELLS
COMPOSITIONS AND PROCEDURES FOR TARGETING IN VITRO AND IN VIVO MEDICINE DELIVERY TO MAMMAL CELLS THROUGH BACTERIALLY DERIVATED INTAKE MINICELLS
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机译:通过细菌来源的摄入微细胞靶向体内和体内向哺乳动物细胞递送药物的组成和程序
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摘要
A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
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