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Programmerbar RNA-fragmentering ved hjælp af TYPE III-A CRISPR-Cas-systemet af Streptococcus thermophilus
Programmerbar RNA-fragmentering ved hjælp af TYPE III-A CRISPR-Cas-systemet af Streptococcus thermophilus
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机译:使用嗜热链球菌的III-A型CRISPR-Cas系统进行可编程RNA片段化
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摘要
A Type III-A CRISPR-Cas (StCsm) complex of Streptococcus thermophilus comprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed.
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