METHODS FOR TREATING A NON-ALCOHOLIC FAT LIVER DISEASE AND / OR LIPODYSTROPHY

摘要

The present invention relates to methods for treating a disease associated with insulin resistance selected from non-alcoholic fatty liver disease (NAFLD) and its complications, lipodystrophic syndrome or a combination thereof, a selective PPARγ agonist, INT131 and optionally vitamin E or compositions thereof. NAFLD, which can be treated with the methods and compositions of the present invention, include, but are not limited to, simple non-alcoholic fatty liver and non-alcoholic steatohepatitis (NASH). Lipodystrophic syndromes that can be treated with the methods and compositions of the present invention include, but are not limited to, generalized lipodystrophy, including congenital generalized lipodystrophy and / or acquired generalized lipodystrophy and / or partial lipodystrophy, including congenital partial lipodystrophy and acquired partial lipodystrophy and each partial lipodystrophy may or may not include hyperplexia and / or hyperglycemia and may or may not include NAFLD.