APPLICATION OF ANTIBODIES OR FRAGMENTS OF ANTIBODIES AGAINST CGRP OR AGAINST CGRP-R FOR TREATMENT OR PREVENTION OF CHRONIC AND ACUTE FORMS OF DIARRHEA

摘要

The present invention relates to methods of treating diarrhea, both chronic and acute, by administering a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular, these methods prevent or ameliorate diarrhea in conditions or treatments resulting in elevated CGRP levels, for example, in the gastrointestinal tract (colon), associated with diarrhea and / or abnormal release of electrolytes and fluids from the intestine or urinary system. More specifically, the present invention relates to methods of treatment with antibodies and fragments against CGRP described herein, and their binding fragments.