CD3-BINDING MOLECULES ARE ABLE TO CONTACT HUMAN CD3 AND CD3 NOT A HUMAN

摘要

The present invention relates to CD3 binding molecules capable of binding to human CD3 and non-human CD3, and in particular to those molecules that cross-react with CD3 of a non-human mammal (e.g., cynomolgus monkey). The present invention also relates to the use of such antibodies and antigen binding fragments for the treatment of malignant neoplasms, autoimmune and / or inflammatory diseases and other conditions.