首页> 外国专利> APPLICATION 1- 4-BROM-5- 1-Ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridine-3-yl -2-fluorophenyl -3-phenylurea AND ANALOGUES FOR TREATING CANCER SPECIES ASSOCIATED WITH GENETIC DISORDERS IN THE ALPH RECIPTOR OF THE PLATFORM GROWTH FACTOR

APPLICATION 1- 4-BROM-5- 1-Ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridine-3-yl -2-fluorophenyl -3-phenylurea AND ANALOGUES FOR TREATING CANCER SPECIES ASSOCIATED WITH GENETIC DISORDERS IN THE ALPH RECIPTOR OF THE PLATFORM GROWTH FACTOR

机译:应用1- [4-BROM-5- [1-乙基-7-(甲基氨基)-2-氧代-1,2-二氢-1,6-萘吡啶-3-基] -2-氟苯基] -3-苯基脲和模拟治疗平台生长因子α受体中与遗传性疾病有关的癌症

摘要

The present invention relates to the use of 1- [4-bromo-5- [1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl] -2-fluorophenyl] -3-phenylureas or 1- (5- (7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -4-bromo-2-fluorophenyl) -3 -phenylurea in the treatment of cancers. In particular, the present invention is directed to methods for inhibiting PDGFR kinases and treating cancers and disorders associated with inhibiting PDGFR kinases, including lung adenocarcinoma, squamous cell carcinoma of the lung, childhood glioblastoma, glioma, astrocytomas, sarcomas, stromal tumors of the gastrointestinal tract , malignant peripheral nerve membrane sarcoma, intimal sarcomas, hypereosinophilic syndrome, idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, acute myeloid leukemia associated with eosinophilia, or lymphoblastic T-cell lymphoma.
机译:本发明涉及1- [4-溴-5- [1-乙基-7-(甲基氨基)-2-氧代-1,2-二氢-1,6-萘啶-3-基] -2的用途-氟苯基] -3-苯基脲或1-(5-(7-氨基-1-乙基-2-氧代-1,2-二氢-1,6-萘吡啶-3-基)-4-溴-2-氟苯基)-3-苯基脲治疗癌症。特别地,本发明涉及抑制PDGFR激酶和治疗与抑制PDGFR激酶相关的癌症和疾病的方法,包括肺腺癌,肺鳞状细胞癌,儿童胶质母细胞瘤,神经胶质瘤,星形细胞瘤,肉瘤,胃肠道间质瘤。道,恶性周围神经膜肉瘤,内膜肉瘤,嗜酸性粒细胞增多综合征,特发性嗜酸性粒细胞综合征,慢性嗜酸性粒细胞白血病,伴有嗜酸性粒细胞增多的急性髓细胞性白血病或成淋巴细胞性T细胞淋巴瘤。

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