APPLICATION 1- 4-BROM-5- 1-Ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridine-3-yl -2-fluorophenyl -3-phenylurea AND ANALOGUES FOR TREATING CANCER SPECIES ASSOCIATED WITH GENETIC DISORDERS IN THE ALPH RECIPTOR OF THE PLATFORM GROWTH FACTOR

摘要

The present invention relates to the use of 1- [4-bromo-5- [1-ethyl-7- (methylamino) -2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl] -2-fluorophenyl] -3-phenylureas or 1- (5- (7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl) -4-bromo-2-fluorophenyl) -3 -phenylurea in the treatment of cancers. In particular, the present invention is directed to methods for inhibiting PDGFR kinases and treating cancers and disorders associated with inhibiting PDGFR kinases, including lung adenocarcinoma, squamous cell carcinoma of the lung, childhood glioblastoma, glioma, astrocytomas, sarcomas, stromal tumors of the gastrointestinal tract , malignant peripheral nerve membrane sarcoma, intimal sarcomas, hypereosinophilic syndrome, idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, acute myeloid leukemia associated with eosinophilia, or lymphoblastic T-cell lymphoma.