METHODS OF TREATING, REDUCING THE INCIDENCE OF, AND/OR PREVENTING ISCHEMIC EVENTS

摘要

The present invention relates to methods of treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing percutaneous coronary intervention (PCI), comprising (1) administering intravenously a 30 μg/kg bolus of cangrelor/kg before the start of PCI; (2) administering intravenously a 4 μg/kg/min continuous infusion of cangrelor after administration of the bolus; wherein the administration of the continuous infusion of cangrelor continues for the longer of (a) at least 2 h, or (b) the duration of PCI; and (3) administering a loading oral dose of ticagrelor in an amount of 180 mg (a) during administration of the continuous infusion of cangrelor, or (b) after discontinuation of the administration of the continuous infusion. The method may further comprise administering an additional therapeutic agent to the patient, the additional therapeutic agent comprising a P2Y₁₂ inhibitor. An ischemic event may include stent thrombosis, myocardial infarction, ischemia-driven revascularization and mortality.