Toll-LIKE RECEPTOR 7 (TLR7) AGONISTS WITH A PYRIDINE OR PYRAZINE FRAGMENT, THEIR CONJUGATES, APPLICATIONS AND METHODS WITH THEM

摘要

Compounds having a structure according to formula (I) wherein R and Ar as defined herein are agonists for Toll-like receptor 7 (TLR7) and can be used as adjuvants to stimulate the immune system. Some of these compounds can be used in conjugates for targeted delivery to an organ or tissue of intended action.