Drug intermediates p-benzoylbenzoic acid synthesis method

摘要

The present invention discloses p-benzoylbenzoic acid synthesis method, comprises the following steps: 3-amino-4-hydroxymethylbenzophenone and potassium nitrate solution were added to the reaction vessel, controlled the stirring speed, raised the temperature of the solution, added 2-methyl-l-butanol solution, added terbium oxide powder in batches; maintain reflux, added potassium bromide solution, precipitateed the crystals, filter, washed with o-xylene solution for several times, washed with hexachloroethane solution for several times, recrystallized in thionyl chloro solution, dehydrated with dehydration, got the finished product of p-benzoylbenzoic acid. Figure 1