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Fusion proteins comprising an endolysin which degrade the cell wall of gram-negative bacteria, compositions comprising the same and uses thereof
Fusion proteins comprising an endolysin which degrade the cell wall of gram-negative bacteria, compositions comprising the same and uses thereof
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机译:包含降解革兰氏阴性细菌细胞壁的内溶素的融合蛋白,包含其的组合物及其用途
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摘要
The present invention relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The present invention also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said fusion protein.
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