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Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2
Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2
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机译:用ccr6或cxcr2拮抗剂治疗广义脓疱型牛皮癣的方法
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摘要
The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula (A):
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