首页>
外国专利>
Probucol-based amorphous pharmaceutical substance, physically stable in the conditions of compression and after compression, and method for obtaining it
Probucol-based amorphous pharmaceutical substance, physically stable in the conditions of compression and after compression, and method for obtaining it
展开▼
机译:在压制条件下和压制后在物理上稳定的基于丙丁酚的无定形药物及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
the object of the application is amorphous pharmaceutical substance based on probukolu, physically stable under compression and after compression, and the way of obtaining.the substance is the double amorphous system two medicines, it is probukolu of model 1 and model 2 of atorvastatin and atorvastatin in share system is at least 9%.the application also includes a way, which is that crystalline pharmaceutical substances in the form of probukolu (4,4 '- [propane - 2,2 - diylbis (thio)] bis (2,6 - di - tert - butylphenolu)) of model 1 and atorvastatin (acid (3r, 5r) - 7 - [2 - (4-fluorophenyl) - 3 - 4 - phenyl - (phenylcarbamoyl) - 5 - propane - 2 - ylopirol - 1 - yl] - 3.5 dihydroksyheptanowego) of model 2, connection,until obtaining a homogeneous mixture, the proportions are chosen to mixture contains at least 9% atorvastatin, subsequently the mixture at a temperature from 125 to merges 150u00b0c,until a full meltdown and a transparent liquid, after which przechu0142adza with cooling speed not slower than 5u00b0c / min,to achieve the temperature below the transition temperature of the vitreous.
展开▼