USE OF ANTIBODIES FOR THOMSEN-FRIEDENREICH ANTIGEN IN A METHOD AND CASE FOR ASSESSING MICROSATELITE INSTABILITY

摘要

THE PRESENT INVENTION REFERS TO THE USE OF ANTIBODIES AGAINST THOMSEN-FRIEDENREICH (TF) ANTIGEN AS REAGENTS FOR THE IN VITRO MICROSSATELLITE INSTABILITY DIAGNOSIS (MSI). THE PRESENT INVENTION ALSO REFERS TO COMPOSITIONS FOR THE IN VITRO DIAGNOSIS OF MSI UNDERSTANDING ANTIBODY ANTIBODIES TF. THIS INVENTION ALSO DISCLOSES A METHOD FOR THE IN VITRO DIAGNOSIS OF MSI THAT UNDERSTANDS CONTACTING THOSE COMPOSITIONS CONTAINING ANTIBODIES FOR THE ANTIGEN TF WITH A TISSUE SAMPLE AND ASSESSING THE EXPRESSION OF THE ANTIGEN TF IN THE CELLS. THIS INVENTION ALSO REFERS TO A CASE UNDERSTANDING THE ABOVE COMPOSITIONS MENTIONED FOR THE DETECTION OF MSI BY CARRYING OUT THE METHOD DISCLOSED IN THE PRESENT INVENTION. THE USE, COMPOSITIONS, METHODS AND CASE OF THE PRESENT INVENTION MAY BE ADVANTAGEALLY APPLIED TO CANCER, INCLUDING NON-LIMITING EXAMPLES OF GASTRIC AND COLORRECTAL CARCINOMAS, TO FACILITATELY FIND THE CLOSER OF THE DIAGNOSTIC INITIATIVE, INITIATIVE INITIATIVE , SIMPLE, FAST, SENSITIVE AND SPECIFIC FOR DIAGNOSIS, PROGNOSIS OR FORECASTING RESPONSE TO IMMUNOTHERAPY TREATMENT.