The present technology relates to processes of preparing leptospirosis vaccines against serovars or serotypes of Leptospira prevalent in the Philippines. Three types of inactivated vaccines were developed based on two identified most prevalent pathogenic Leptospira serovars circulating in the Philippines, namely, Manilae and Losbanos. The vaccines that have been developed are: (1) Monovalent Manilae, (2) Monovalent Losbanos, and (3) Bivalent Manilae and Losbanos (homologous challenge with serovars Manilae and Losbanos and heterochallenge with serovar Grippotyphosa and serovar Canicola). The vaccines that were produced through the developed process were assessed on their safety, immunogenicity and efficiency. The main advantage of these vaccines is their serovar-specificity for the pathogenic Leptospira serovars that are locally prevalent which would ensure an effectively directed program of preventive control of leptospirosis in animals which can be translated to effective leptospirosis prevention among humans.
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