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A UNIVERSAL VACCINE BASED ON SHARED TUMOR NEOANTIGENS FOR PREVENTION AND TREATMENT OF MICRO SATELLITE INSTABLE (MSI) CANCERS
A UNIVERSAL VACCINE BASED ON SHARED TUMOR NEOANTIGENS FOR PREVENTION AND TREATMENT OF MICRO SATELLITE INSTABLE (MSI) CANCERS
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机译:基于肿瘤新抗原的通用疫苗预防和治疗微卫星不稳定(MSI)癌症
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摘要
This invention relates to a method of selecting a collection of frame-shift peptides (CFSPs) to produce a universal cancer vaccine peptide collection (CVP) for prophylaxis and treatment of patients with hereditary and sporadic micro-satellite instability (MSI) tumors. This invention relates as well to a method of producing a CVP by selecting a subset of frame-shift peptides (FSPs) from the CFSP and optionally modifying the FSP's amino acid (aa) sequence to generate modified FSPs (mFSPs). The invention further relates to nucleic acid collections encoding a CVP of FSPs and/or mFSPs in one or more vaccine vectors that can be used also simultaneously. These CVPs, nucleic acids and vectors are used for the prophylaxis or treatment of MSI cancers.
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