A universal vaccine based on shared tumor neoantigens for prevention and treatment of micro satellite instable (MSI) cancers

摘要

This invention relates to a method of selecting a collection of frame- shift peptides (CFSPs) to produce a universal cancer vaccine peptide collection (CVP) for prophylaxis and treatment of patients with hereditary and sporadic micro- satellite instability (MSI) tumors. This invention relates as well to a method of producing a CVP by selecting a subset of frame-shift peptides (FSPs) from the CFSP and optionally modifying the FSP's amino acid (