IMMUNE RESPONSE PROFILING OF TUMOR-DERIVED EXOSOMES FOR CANCER DIAGNOSIS

摘要

The present invention generally relates to the generation of tumour-derived exosome-induced immune response or cancer-specific response profile by isolating tumour-derived exosomes from blood sample of a patient having a specific cancer type, and measuring in vitro immunological impacts of tumour-derived exosomes on immune cells, in particular T cells. The tumour-derived exosome-induced immune response or cancer-specific response profile created can be used in methods for detecting or diagnosing cancer or cancer type in a subject and for identifying whether a subject having a cancer type is responding to treatment of that cancer type.