Pyrazine- 1,2-a indole compounds, their preparation and use in medicinal products

摘要

A compound of general formula (I), or a pharmaceutically acceptable enantiomer, diastereoisomer, racemate, solvate, or salt thereof: ** Formula ** wherein m is selected from 0.1, 2, 3 and 4; n is selected from 0, 1, 2, 3 and 4; represents a single or double bond; R1 represents one or more optional and independent substitutions on the benzene moiety selected from the group consisting of alkyl and halogen; R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl, or R2 and R3 together form a cycloalkyl or heterocyclyl; R4 and R5 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl, or R4 and R5 together with the bridging nitrogen atom form a substituted or unsubstituted heterocyclyl, wherein said non-substituted heterocyclyl it is a phthalimidyl; R6 is selected from the group consisting of hydrogen and alkyl; wherein the substituted groups defined above are substituted at one or more available positions by one or more suitable groups selected from OR ', = O, SR', SOR ', SO2R', OSO2R ', OSO3R', NO2, NHR ', N (R ') 2, = N-R', N (R ') COR', N (COR ') 2, N (R') SO2R ', N (R') C (= NR ') N (R' ) R ', N3, CN, halogen, COR', COOR ', OCOR', OCOOR ', OCONHR', OCON (R ') 2, CONHR', CON (R ') 2, CON (R') OR ', CON (R ') SO2R', PO (OR ') 2, PO (OR') R ', PO (OR') (N (R ') R'), C1-C12 alkyl, C3-C10 cycloalkyl, C2 alkenyl - C12, C2-C12 alkynyl, aryl and heterocyclic group, wherein each of the R 'groups is independently selected from the group consisting of hydrogen, OH, NO2, NH2, SH, CN, halogen, COH, COalkyl, COOH, C1-C12 alkyl, C3-C10 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl and heterocyclic group.