7-Phenylethylamino-4H-pyrimido 4,5-D 1,3 oxazin-2-one compounds and their use as mutant IDH1 inhibitors

摘要

A compound of the formula: ** (See formula) ** wherein L is a linker selected from the group consisting of -N-azetidine-3-CH2-O-, -N-azetidine-3-O- ( CH2) -, -N- 2,6-diazaspiro [3,3] heptane-6- (CH2) -, -N-piperazine-4- (CH2) -, -N-piperazine-, -N-azetidine-3 - (CH2CH2) -, -7-N- (2,7-diazaspiro [3.5] nonane) -2- (CH2), -N-azetidine-3- (NMe) CH2-, -N-piperidine-4 - (NMe) CH2-, N-2,5-dihydropyrrole-3- (CH2) -O-; Z is selected from the group consisting of H or F; R is selected from the group consisting of C1-C4 alkyl, -CH (CH3) CH2-OH, -CH2CH2F, -CH2CHF2; or a pharmaceutically acceptable salt thereof.